百林科兰州层析填料全新蛋白A及羟基磷灰石B15智能车间正式落成投运，
标志着百林科在制药核心耗材"国产替代"道路上，又一次从技术突破到大规模、高质量稳定供应的关键跨越。 The Chips Act is "a pre-cursor to further escalations with China in order to flip this dynamic, knowing that the US will not be able to adequately defend Taiwan,” US-based financial commentator Tom Luongo tells Sputnik, referring to US-Chinese tensions over Taipei, which escalated after House Speaker Nancy Pelosi’s visit to the island last week.,"The US will defend Taiwan through a number of hybrid war tactics, including sanctions and tariffs as well as monetary policy, while simultaneously making like they can and will defend Taiwan militarily. For now, Taiwan is important, this bill is saying we need to ensure it is less important. This vulnerability, in my opinion, was deliberately pursued by forces within our government to lead us to this unfolding crisis. We always wanted a casus belli against China. Taiwan is the perfect trip wire for further war," Luongo explains.,He ventured to say that “it may even have been the reason” Pelosi visited Taiwan “to ratchet up the tension and ensure the bill’s passage,” adding that “at this point, things are so murky, trying to divine what anyone’s motivations are on Capitol Hill, other than surviving the mid-terms, is a fool’s errand.”,Earlier this week, US President Joe Biden signed a bipartisan bill that aims to boost the country’s competitiveness with China by investing $280 billion in domestic semiconductor manufacturing and science research.,Speaking at the signing ceremony outside the White House on Tuesday, Biden claimed that “the future of the chip industry is going to be made in America,” adding, “Today is a day for builders. Today America is delivering.”,Dubbed the Chips and Science Act, the bill includes more than $52 billion for US companies producing computer chips, as well as billions more in tax credits to encourage investment in semiconductor manufacturing.,WorldUS New Chips Law Will Undermine Global Supply Chains: Chinese Foreign MinistryYesterday, 12:00 GMT,The document also stipulates allocating tens of billions of dollars to fund scientific research and development and to spur the innovation and development of other US technology.,"Trade tensions with China and the war hysteria [around] Taiwan will make US susceptible to disruptions in chip availability that can have wide ranging disturbances across industries," says Dr. Sunita Raju, a professor of economics and Chairperson of the Indian Institute of Foreign Trade. "While the CHIPS Act is an effort to maintain technology leadership position of US, it is also an effort to stem the US lagging behind Taiwan, Korea and China in recent times in chip manufacturing.",The Chips Act is "a clear departure for US industrial policy to provide subsidies and incentives to a specific industry. The compulsion now is driven by geopolitical tensions (US-China trade war, China-Taiwan-US confrontation), strategic significance of chips in manufacturing across industries (particularly post COVID) and its applications for defence and national security concerns," says Dr. Raju.,The professor explains that the purpose is to attact investment from major chip manufacturers and establish semiconductor fabrication plants in the United States.,"The 'Fab less' model that the US followed in the past made US gain a dominant market position in the R&D, IP and design capability of the value chain of semiconductor industry but resulted in less than 12% in wafer fabrication (capital intensive) and 2% in Assembling, Packaging &Testing (Capital & labour intensive) (SIA, 2021). US share in global installed capacity of semiconductor industry is less than 12%, while the global sale of semiconductor sales (Fab less plus IDMs) is 48%. As a result, growth in installed capacity of US was outpaced by Asian countries," Dr. Raju explains.,Modi Vows to Develop India as Chip Hub as Gov't Sets $300Bn Target in Electronics Manufacturing 4 July, 20:01 GMT,Meanwhile, Luongo says that the bill “will have an effect on semiconductor production” in the US, but “the question is whether it is cost-effective to actually do it.”,“It was a strategic mistake to offshore all of our chip production. For everything outside of the bleeding edge in power management – phones, data centers, etc. – older technology is just fine. Remember that most of these big chips are designed here in the US, manufacturing happens overseas. […] The production of most of your iPhone happens here in the US, the assembly of the parts happens in China. This point is lost in all of the noise,” he points out.,Luongo describes the bill as “just a start” in terms of the US’ effort to get the better of China in the race to dominate the high-tech sector.,“The turnaround will take time certainly, there is no easy fix here (…) If the US is serious about gaining real market share and competitiveness in manufacturing, then a lot of roadblocks currently in place will need to end,” the commentator notes.,He went on to argue that the global market for chips currently looks “the way it does because of US technology barriers through trade deals, sanctions and the like.” Luongo adds that US foreign policy “will now hinge on continuing to try and delay and slow down the rise of competition” and that “being pushed out of markets like central Asia and falling behind in Africa, etc. isn’t a good sign.”,According to him, “the real problem now is that the US is going hyper-belligerent to maintain its control when it should have looked inward to solve its internal problems years ago. [Former US President Donald] Trump tried and failed to make meaningful reforms.”。以"筑基智能制造，层析健康未来"为主题的B15填料自动化产线投运启动活动，在兰州新区政府的大力支持下成功举行。
二 | 百林科管理团队与生物制药产业链的关键行业伙伴，共同见证新车间及自动化产线正式投入运行。
图1：百林科管理层（从左至右：副总裁张天勇、创始人兼董事长陈志、首席执行官张铮、副总裁王智）共同为B15填料自动化产线投运启幕全新的B15 蛋白A及羟基磷灰石车间的落成投运，在百林科独特且稳定的生产工艺上结合了全自动化控制，是百林科持续推进层析填料产业化和智能制造建设的重要一步。
三 | 作为兰州新区生物医药产业布局的一部分，百林科兰州基地经过持续建设，已逐步形成覆盖研发、生产及质量管理等环节的产业化体系。此次新产线投运，将进一步提升基地自动化生产、规模化制造及供应保障能力，为层析填料业务持续发展提供更加坚实的制造支撑。
图2：启幕仪式在关键行业伙伴的见证及兰州新区政府的大力支持下举行B15车间正式投运，智造能力再升级B15车间主要布局蛋白A全自动偶联生产线及羟基磷灰石生产线，是百林科进一步完善层析填料自动化生产体系的重要布局。目前，百林科兰州基地已建成1条500L及3条1000L全品类层析填料自动化生产线，以及一条在建的硬胶自动化生产线。搭配一条全自动灌装线, 实现智能制造全流程贯穿，有效提升效率与批次一致性，整体自动化率达到90%。
四 | 其中，琼脂糖葡聚糖层析填料年产能可达 25万升, 羟基磷灰石年产能达10吨，并配备3000余平方米甲类防爆厂房，以及GMP标准D级洁净分装区及仓储区，为层析填料规模化生产提供制造基础。
五 | 百林科创始人兼董事长陈志表示，自兰州填料智能制造基地建设之初，百林科就希望将其打造成为集研发、与产业化于一体的层析填料基地。B15车间的落成投运，不仅是生产设施的进一步完善，更是百林科持续提升制造能力和供应保障能力的重要一步。
六 | "智能制造的核心并不只是提高生产效率，更重要的是建立更加稳定、可控的生产体系，为客户提供稳定的产品和供应保障。
七 | "陈志表示。
八 | 未来，百林科将持续推动产品、技术与制造能力协同发展，与客户共同推动国产层析填料从产品替代走向更广泛的规模化应用。
图3：B15车间内的蛋白A全自动偶联生产线全品类布局持续完善，产业化能力进一步提升B15新产线的投入运行，也进一步完善了百林科兰州基地的层析填料产品及生产布局。目前，百林科层析填料产品已覆盖葡聚糖琼脂糖软胶、聚合物硬胶、羟基磷灰石等多个产品类别，涵盖离子交换、亲和、疏水、过滤、多模式、反向等层析原理，形成百余种细分产品。此次B15车间投运，将进一步增强蛋白A、羟基磷灰石等产品的规模化生产能力，并与基地现有自动化生产线形成协同，推动百林科层析填料从多产品布局向更加完善的全品类产业化体系发展。
九 | 与此同时，兰州基地通过DCS自动化控制系统及GDS系统，对生产过程进行数字化管理与安全控制，实现关键工艺参数的实时监测与自动控制，持续提升生产流程的标准化、数字化和自动化水平。2024年，兰州基地还获评甘肃省"数字化车间"。
图4：百林科兰州层析填料智造基地屡获“数字化车间”等殊荣以智能制造支撑国产层析填料发展随着生物医药产业持续发展，层析填料作为生物制药下游纯化环节的重要材料，其产品性能、质量稳定性和供应能力受到越来越多关注。
十 | 对于国产层析填料而言，从产品研发走向规模化应用，不仅需要持续突破核心技术，也需要稳定、可靠的产业化制造能力。B15车间的正式投运，正是百林科围绕这一目标持续投入的重要成果。未来，百林科将持续推进核心技术研发、产品创新与智能制造能力建设，不断完善层析填料产品与产业化布局，以更加稳定、高效的制造能力，为生物制药客户提供高品质、高可靠性的层析填料及生物工艺解决方案。筑基智能制造，层析健康未来。赋能生物技术，通达无限可能。
